Official websites use. Share sensitive information only on official, secure websites. Email: amine. They are aggressive tumors where location, size, and management require a multidisciplinary approach. Since there are few series published, we here analyze epidemiological pattern, clinical and pathologic features of soft tissue leiomyosarcomas. We conducted a retrospective study of 29 consecutive cases of histologically proven soft tissue leiomyosarcoma extracted from the database of the Cancer Registry of the Center of Tunisia and the Department of Pathology of Farhat Hached University Hospital of Sousse of Tunisia, during a year period from January to December Soft tissue leiomyosarcoma accounted for Deep sites as retroperitoneum was found only in two cases.
Five cases had metastasis on initial staging. For 24 patients, the disease was locally limited at the moment of diagnosis. Palliative chemotherapy was indicated for four patients and surgery was performed for 20 patients. Our study results highlight the scarcity of soft tissue leiomyosarcoma. Clinical course of soft tissue leiomyosarcoma was highly marked by local recurrence and metastasis.
Leiomyosarcoma LMS of soft tissue is a relatively uncommon malignant tumor that has the phenotypic features of smooth muscle differentiation and may occur anywhere in the body. It is frequently encountered in subcutaneous or in deep soft tissues of limbs, head and neck, and retroperitoneum. Data on soft part LMS were scanty. Most epidemiological studies of soft tissue sarcoma STS were performed in the Western countries, and only limited data highlight that in the Asian population.
To our knowledge, soft tissue LMS has not been described in any large previous study with complete follow-up, in North Africa. We included patients with subcutaneous and deep-seated LMS of extremities, trunk wall, retroperitoneum, and head and neck region. All of them had nearly complete clinical data regarding tumor size and depth, imaging, treatment modalities, and outcome.
Patients with cutaneous, mediastinal, gynecologic, genitourinary, intra-thoracic, and major vessel LMS were excluded. All histological slides were reevaluated by two experienced pathologists.
